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KMID : 0923620140140050255
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Immune Network
2014 Volume.14 No. 5 p.255 ~ p.259
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Effects of Endurance Training on the Serum Levels of Tumour Necrosis Factor-α and Interferon-γ in Sedentary Men
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Jahromi Abdolreza Sotoodeh
Zar Abdossaleh
Ahmadi Fatemeh
Krustrup Peter
Ebrahim Khosrow
Hovanloo Friborz
Amani Davar
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Abstract
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Physical activity could be considered one of the factors that affect the immune system status and function. To find the re-lation between exercise and cytokines, we examined the pos-sible effects of an 8-week endurance training program on the serum levels of cytokines, including tumour necrosis fac-tor-alpha (TNF-α) and interferon-gamma (IFN-γ) in seden-tary men. A total of 30 healthy young male volunteers were randomly divided into an endurance training group and a con-trol group. The training group followed a specific exercise protocol (running on a treadmill for 15∼30 min at 50∼70% maximal heart rate) for 8 weeks and the control group did not participate in any exercise program. Venous blood samples were collected from both the groups 24 h before and 24 h and 48 h after the exercise. Repeated ANOVA was used for statistical purposes. The serum levels of TNF-α and IFN-γ were determined by ELISA. Significant (p＜0.05) and non-significant (p＞0.05) decreases were observed in the serum levels of IFN-γ and TNF-α, respectively, after the 8-week endurance training program. Our findings indicated that an 8-week endurance exercise may affect the serum lev-els of some inflammatory cytokines, suggesting the benefi-cial role of this training protocol in elderly population and people with certain conditions (inflammation of the vertebrae or other inflammatory diseases).
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KEYWORD
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Cytokine, Endurance exercise, IFN-γ, TNF-α
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